Cast Nephropathy: Removal of Serum Free Light Chains by High Cut-off Hemodialysis
نویسندگان
چکیده
منابع مشابه
Aggregated serum free light chains may prevent adequate removal by high cut-off haemodialysis.
Free light chain (FLC) removal by high cut-off haemodialysis has been described as an adjuvant therapy for the management of patients with severe renal failure complicating multiple myeloma. The two cases reported here are the first patients in whom this treatment did not remove FLCs. In both patient's sera, size-exclusion chromatography identified large FLC aggregates, with molecular weights a...
متن کاملHigh cut-off dialyser haemodialysis in cast nephropathy
Sir, The importance of renal function in the prognosis of patients with multiple myeloma (MM) has been well established and rapid reversal of renal failure may offer the best long-term outcome. The use of extracorporeal means of removing immunoglobulin free light chains (FLCs) responsible for cast nephropathy in patients with MM is controversial. Nephrologists are interested in a treatment stra...
متن کاملEffective Removal of κ-Free Light Chains with Hemodialysis Using Fresenius Ultraflux® EMiC®2 Dialyser in a Patient with Myeloma Cast Nephropathy, with Associated Cost Savings.
with cyclophosphamide. For AKI due to probable cast nephropathy, HCO HD with Fresenius Ultraflux ® EMiC ® 2 dialyser, 8 h/ session, 5 days/week was commenced. After 2 weeks of treatments, although κ-FLC Dear Editor, Cast nephropathy is the commonest cause of acute kidney injury (AKI) in patients with multiple myeloma (MM) [1] . There has been a recent interest in extended hemodialysis (HD) with...
متن کاملDiagnostic accuracy of monoclonal antibody based serum immunoglobulin free light chain immunoassays in myeloma cast nephropathy
UNLABELLED BACKGROUND The development of serum immunoassays for the measurement of immunoglobulin free light chains has led to a paradigm shift in the diagnosis, assessment and monitoring of patients with plasma cell dyscrasias. The impact of these immunoassays which employ polyclonal antibodies was most notable for those patients who were previously classified as non-secretory multiple myel...
متن کاملEuropean trial of free light chain removal by extended haemodialysis in cast nephropathy (EuLITE): A randomised control trial
BACKGROUND Renal failure is a frequent complication of multiple myeloma and when severe is associated with a greatly increased morbidity and mortality. The principal cause of severe renal failure is cast nephropathy, a direct consequence of high concentrations of monoclonal free light chains (FLCs) in patients' sera. FLC removal by extended haemodialysis, using a high cut-off dialyser, has rece...
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ژورنال
عنوان ژورنال: Hong Kong Journal of Nephrology
سال: 2015
ISSN: 1561-5413
DOI: 10.1016/j.hkjn.2015.09.178